From what I gathered from the on-line Lexus Maintenance Menu, the "significant" service interval is every 30,000 miles. This includes REPLACING the oil and oil filter, air conditioner filter, brake fluid, engine air filter and smart key battery. This also includes INSPECTING the brake pad thickness and rotor runout, axle shaft boots, ball joints and dust covers, body, brake lines and hoses, engine coolant, exhaust pipes and mounting, fuel lines and connections, fuel tank band and fuel tank vapor vent system hoses, fuel tank cap gasket, rack and pinion steering assembly, rear differential oil, steering linkage and boots, and transmission for signs of leakage. Therefore, I would conclude that as long as you inspect the brakes and tire tread wear every 5,000 miles, we should be able to limit our oil and filter changes using synthetic oil to every 10,000 miles and do the recommended 30,000 mile service as indicated above.